- Case Report
- Open access
- Published:
Hypokalemic periodic paralysis as the first sign of thyrotoxicosis- a rare case report from Somalia
Thyroid Research volume 16, Article number: 14 (2023)
Abstract
Background
Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare complication of hyperthyroidism characterized by thyrotoxicosis, hypokalemia, and paralysis. It is the most common form of acquired periodic paralysis. THPP is precipitated by strenuous exercise, a high carbohydrate diet, stress, infection, alcohol, albuterol, and corticosteroid therapy. It is most common in Asian men with hyperthyroidism and exceptionally rare in black people.
Case Presentation
A 29-year-old man was admitted to the emergency department in Somalia with a sudden onset of paralysis after a high carbohydrate meal. Laboratory investigations showed low serum potassium 1.8 mEq/l (3.5–4.5), and biochemical thyrotoxicosis with TSH 0.006 miu/l (0.35–5.1), total T3 3.2 ng/ml (0.9–2.8) and total T4 13.5 ng/ml (0.6–1.2). He was successfully treated with potassium chloride infusion and an antithyroid drug, methimazole.
Conclusion
To prevent life-threatening cardiac and respiratory complications, it is critical to consider and diagnose THPP early, even in populations where the condition is rare.
Introduction
Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare endocrine disorder characterized by the triad of thyrotoxicosis, hypokalemia, and sudden muscle weakness. It is most commonly seen at night [1]. The proximal muscles are more severely affected than the distal ones. The lower limbs are usually affected first, followed by the girdle muscles and the upper limbs. The sensory system remains unaffected [2].
THPP is a rare cause of paralysis in the general population. It is most common in the Asian populations, where it affects about 2% of hyperthyroid individuals. In contrast, it is rare in non-Asian populations, where the incidence is estimated to be between 0.1 and 0.2% among patients with hyperthyroidism [3]. It occurs 70 times more frequently in men than in women and typically occurs between the ages of 20 and 40 [4].
The mechanism through which hyperthyroidism results in hypokalemic periodic paralysis is unknown. Thyroid hormone improves tissue response to beta-adrenergic stimulation, which increases sodium-potassium ATPase activity on the skeletal muscle membrane in combination with thyroid hormone [5].
The presence of both profound hypokalemia and biochemical thyrotoxicosis (increased serum levels of thyroxine and triiodothyronine with suppressed TSH) confirms the diagnosis of THPP. Its treatment comprises of correcting hypokalemia for immediate reversal of paralysis and restoring normal thyroid status to prevent future THPP attacks [6].
Here, we report a case of a young man, who presented to the emergency department in Somalia with a sudden onset of paralysis due to THPP.
Case presentation
A 29 years old man was admitted to the emergency department with a sudden onset of paralysis. He had gone to bed and slept at 15:30 with no symptoms and awoke in the evening unable to move his upper or lower extremities. The weakness was bilateral, and also involved proximal muscles of shoulders and hips. He had no dysphagia and shortness of breath. He could talk and move his neck. Before he went to the bed, he had eaten a high carbohydrate meal. He denied fever, recent diarrhea, chest pain, and a history of strenuous exercise. Before this episode, the patient was experiencing bilateral cramp-like leg pain for 1 month, but he had not sought medical advice. He had no past history of any chronic disease, or a family history of such episodes.
On examination, the patient was conscious, alert, and oriented to time, place, and person. His blood pressure was 120/60 mmHg, heart rate of 75 beats per minute, the temperature of 36.5 degrees centigrade, respiratory rate 36 breaths per minute, and sp02 96% in room air. He had no jaundice, conjunctival hemorrhage, photophobia, palpable mass on his neck or lymphadenopathy. There was no lower limb edema. The lung and abdominal examinations were unremarkable. Neurological examination showed reduced muscle power in all four limbs to 1/5, his cranial nerves were intact, and there was no bladder or bowel dysfunction.
His initial investigations showed marked hypokalemia at 1.8 mEq/L (reference range 3.5–4.5) (Table 1). Electrocardiography showed T wave inversion, ST depression and prominent U waves.
We started an intravenous infusion of potassium chloride at 10 mEq/L/hr. After 6 h of potassium replacement, he regained his distal muscle movement when his serum potassium was 2.4 mEq/L. His neurological symptoms completely resolved after 12 h of potassium supplementation, when his potassium was 4.24 mEq/L.
To determine the cause of his hypokalaemic paralysis, we checked his thyroid function tests, which showed biochemical thyrotoxicosis with fully suppressed thyroid-stimulating hormone (TSH) with elevated total T3 and total T4 levels (Table 1). His anti-thyroid peroxidase (TPO) antibodies were negative, TSH-receptor antibodies were not checked. Thyroid ultrasound revealed increased thyroid size, with hypervascular parenchymal echogenicity.
The next day, the patient was stable, and we discharged him with methimazole 30 mg/day, with a follow-up in the outpatient clinic.
Discussion
Our patient exhibited lower motor neuron quadriparesis with no bladder or bowel problems in association with severe hypokalemia and biochemical thyrotoxicosis, consistent with the diagnosis of THPP. Flaccid quadriparesis can also be caused by Guillain-Barre Syndrome, transverse myelitis, myasthenia gravis, tick paralysis, or botulism. There was no sensory impairment or bladder/bowel involvement in our patient, therefore transverse myelitis was ruled out. Typical clinical features of myasthenia gravis such as diurnal fluctuation of weakness, facial weakness, or eyelid drooping were absent. There were no symptoms of botulism like fever or food poisoning. The patient was first suspected of having Guillain-Barre syndrome, but an arterial blood gas (ABG) showed hypokalemia with a normal pH. The patient denied any personal or family history of such occurrence of paralysis. Familial periodic paralysis, spontaneous periodic paralysis, and THPP are other differential diagnoses in our patient. The diagnosis of THPP was confirmed following thyroid function test showing biochemical thyrotoxicosis in association with severe hypokalaemia and paralysis.
Hypokalemic periodic paralysis is a rare and can be either primary (familial) or secondary (environmental). Hyperthyroidism and a variety of other disorders, such as hyperaldosteronism, diabetic ketoacidosis, nephrotic syndrome, medications, acute tubular necrosis, laxative or diuretic usage, diarrhea, and vomiting, are examples of secondary causes [7]. To exclude the primary causes (familial periodic paralysis), we couldn’t do a genetic test as it is not available in our country. THPP is common in Asian men, including Chinese, Japanese, Vietnamese, Filipinos, and Koreans, and Graves’ disease is the most common cause of hyperthyroidism associated with THPP [8]. THPP is an uncommon condition, so additional diagnoses such as familial hypokalemic periodic paralysis, myasthenia gravis, Guillain-Barre Syndrome, viral and inflammatory myopathies, transverse myelitis, cord compression, and other electrolyte abnormalities should be evaluated. These causes can be ruled out based on the history, physical examination, and other tests [9]. Many patients with THPP have no overt symptoms or signs of thyrotoxicosis. Because the condition is uncommon in non-Asian populations, it is commonly misdiagnosed [2].
A high-carbohydrate, high-salt diet, alcohol consumption, trauma, menstrual cycle, infections (including viral gastroenteritis), certain medications (e.g., steroids, diuretics, epinephrine, acetazolamide, and insulin), and strenuous exercise are potential precipitating factors for THPP in patients with underlying thyrotoxicosis [10]. Our patient had a high carbohydrate meal before he slept.
Deaths from respiratory paralysis and heart failure have been reported in THPP, even though the condition is rarely life-threatening and rarely involves the cranial nerves. The paralysis usually resolves in 3–36 h, in the reverse sequence in which it appeared. Serious morbidity, such as dysrhythmias, ventilator failure, and death, is uncommon [4].
The pathophysiology of THPP remains unclear. Membrane excitability and muscle contraction are controlled by sodium, chloride, calcium, and potassium channels on cell membranes. Disruption of any of these cellular transport mechanisms, particularly the potassium ion channel, can result in aberrant muscle contractility and paralysis. The main defect in THPP is a rapid increase in intracellular potassium. This is related to genetic abnormalities in the Na+/K + ATPase pump in the majority of instances [4]. Thyroid hormone stimulates Na+–K + ATPase in skeletal muscle via genomic mechanisms that work on thyroid hormone-responsive regions to upregulate the transcription of the Na+–K + ATPase gene, as well as nongenomic mechanisms that raise the pump’s intrinsic activity or facilitate membrane insertion. Hyperthyroidism may enhance the activation of pump-action by b2-adrenergic agonists by increasing intracellular cAMP synthesis. Hyperinsulinemia is also seen in acute THPP attacks, and insulin release in response to oral glucose challenge is increased in patients with THPP, implying that insulin plays a role in the pathophysiology of hypokalemia in THPP [1].
Aside from potassium supplements, acute THPP is treated by immediately reducing thyroid hormone levels. It is vital to remember that during the recovery period, the release of potassium and phosphate from the cells can contribute to rebound hyperkalemia. Intravenous potassium therapy for hypokalemia causes a faster response than oral supplements. Prophylactic potassium dosage between attacks has not been proven to be useful. Non-specific beta-blockers have been shown to reduce the frequency and severity of episodes. Hyperthyroidism should be controlled to prevent attacks of muscle weakness [10]. Only a few cases of THPP have been reported from African populations [11].
Conclusion
THPP as the first manifestation of thyrotoxicosis is rare, as our patient had no history of hyperthyroidism. This disorder is rare among African populations. THPP is frequently misdiagnosed in non-Asian populations because it resembles familial periodic paralysis. Early detection, effective treatment, and prevention of rebound hyperkalemia will all benefit from an increased awareness of this disorder.
Data Availability
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Abbreviations
- THPP:
-
Thyrotoxic hypokalemic periodic paralysis
- TSH:
-
Thyroid stimulating hormone
- ATP:
-
Adenosine triphosphate
- cAMP:
-
Cyclic adenosine monophosphate
References
Meseeha M, Parsamehr B, Kissell K, Attia M. Thyrotoxic periodic paralysis: a case study and review of the literature. J Community Hosp Intern Med Perspect. 2017;7(2):103–6.
Kung AWC, Clinical, Review. Thyrotoxic periodic paralysis: a diagnostic challenge. J Clin Endocrinol Metab. 2006;91(7):2490–5.
Patrick K. Thyrotoxic periodic paralysis in United States Report of 7 cases and review of the literature. Med (Baltim). 1992;71(3):109–20.
Report C. Thyrotoxic hypokalemic periodic paralysis in a turkish male with Graves. ’ Disease. 2005;27(1):63–5.
Rhee EP, Scott JA, DA S, Dighe AS. Case 4-2012. A 37-year-old man with muscle pain, weakness, and weight loss. N Engl J Med [Internet]. 2012;366(6):553–60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22316449.
Khadka S, Indu KC, Rayamajhi RJ, Dawadi P, Budhathoki P. Thyrotoxic periodic paralysis with hypokalemia in an adult male from nepal: a case report. J Nepal Med Assoc. 2019;57(220):468–71.
Al Moteri BL, Aslam M. Thyrotoxic periodic paralysis: a case report. Int J Health Sci. 2017 Jan;11(1):1.
Patel M, Ladak K. Thyrotoxic periodic paralysis: a case report and literature review. Clin Med Res. 2021;19(3):148–51.
Batch JT, Jahngir MU, Rodriguez I. Thyrotoxic Periodic Paralysis: An Incidental Diagnosis! Cureus. 2020;12(2).
Lin SH, Huang CL. Mechanism of thyrotoxic periodic paralysis. J Am Soc Nephrol. 2012;23(6):985–8.
Munir I, Mehmood T, Islam K, Soni L, McFarlane SI. Thyrotoxic periodic paralysis with sensory deficits in young african american male: a case report and literature review. Am J Med case Rep. 2019;7(7):138.
Funding
None.
Author information
Authors and Affiliations
Contributions
Hawa Nuradin Mohamed, Abdi Karim Ahmed Ghedi and Sevgi Ozturk collected information on the patient. Hawa Nuradin Mohamed wrote the first draft. Mohamed Osman Omar Jeele and Ahmed Muhammad Bashir did the literature searches and wrote the final manuscript and made appropriate revisions. All authors read through and approved the final manuscript.
Corresponding author
Ethics declarations
Competing Interest
The authors declare no competing interests.
Ethics approval and consent to participate
Ethical approval is waived from case reports in our hospital.
Consent for publication
Written and informed consent was taken from the patient for the publication of the case.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Mohamed, H.N., Ghedi, A.K.A., Ozturk, S. et al. Hypokalemic periodic paralysis as the first sign of thyrotoxicosis- a rare case report from Somalia. Thyroid Res 16, 14 (2023). https://doi.org/10.1186/s13044-023-00158-4
Received:
Accepted:
Published:
DOI: https://doi.org/10.1186/s13044-023-00158-4