Table 4 Distribution of IKBL and NFKBIA genotypes in subgroups of patients with Graves' disease stratified by clinical activity of thyroid associated ophtalmopathy assessed according to the OSPECS classification.
Gene | polymorphism | genotype | Ophtalmopathy | p/pc value OR (95%CI) | |||
|---|---|---|---|---|---|---|---|
NOSPECS ≥ III (%) N = 170 | NOSPECS ≤ II (%) N = 289 | ||||||
IKBL | promoter -62 | TT | 65 | (38.2) | 105 | (36.3) | NS |
AT | 81 | (47.6) | 140 | (48.4) | |||
AA | 24 | (14.1) | 44 | (15.2) | |||
intron 1 | CC | 68 | (40.0) | 108 | (37.4) | NS | |
CT | 86 | (50.6) | 145 | (50.2) | |||
TT | 16 | (9.4) | 36 | (12.4) | |||
exon 4 | TT | 156 | (91.8) | 268 | (92.7) | NS | |
CT | 14 | (8.2) | 21 | (7.3) | |||
CC | 0 | (0.0) | 0 | (0.0) | |||
NFKBIA | 3'UTR | GG | 53 | (31.2) | 101 | (35.0) | NS |
AG | 90 | (52.9) | 133 | (46.0) | |||
AA | 27 | (15.9) | 55 | (19.0) | |||
promoter -297 | CC | 107 | (62.9) | 213 | (73.7) | p = 0.01* | |
CT | 54 | (31.8) | 72 | (24.9) | pc = 0.18 | ||
TT | 9 | (5.3) | 4 | (1.4) | OR = 1.65 (1.10-2.48) | ||
promoter -826 | CC | 101 | (59.4) | 205 | (70.9) | p = 0.01* | |
CT | 59 | (34.7) | 80 | (27.7) | pc = 0.18 | ||
TT | 10 | (5.9) | 4 | (1.4) | OR = 1.67 (1.12-2.48) | ||