Cytometric evaluation of intracellular IFN-γ and IL-4 levels in thyroid follicular cells from patients with autoimmune thyroid diseases

Table 1 Data of patients with GD before methimazole therapy, after six months of therapy (prior to surgery) in non-toxic multinodular goiter and HT

	Untreated GD group Group A	Group after six months of methimazole therapy Group A'	Group with HT Group B	Group with non-toxic multinodular goiter Group C	P
Age (years)	15.4 ± 2.1	16.4 ± 3.3	16.8 ± 2.8	15.8 ± 1.8	NS, NS, NS*
n	18	18	18	18
Weight (kg)	57 ± 11.0	59 ± 7	63 ± 8	62 ± 7	NS, NS, NS*
Height (cm)	166 ± 3	169 ± 1	170 ± 5	169 ± 7	NS, NS, NS*
BSA (m ² )	1.66	1.68	1.7	1.67	NS, NS, NS*
anti-TPO (IU/ml)	1250 ± 350	650 ± 250	1550 ± 500	41.3 ± 38	p < 0.0001, p* < 0.01, p** < 0.001
anti-TG (IU/ml)	630 ± 262	360 ± 40	820 ± 150	180 ± 86	p < 0.001, p* < 0.01, p** < 0.001
TRAb (U/l)	> 5 positive	> 3 positive	(-)	(-)
fT4 (ng/dl)	5.9 ± 2.0	2.04 ± 0.3	1.29 ± 0.2	1.1 ± 0.2	p < 0.001, NS, NS*
fT3 (ng/dl)	8.85 ± 2.1	3.8 ± 0.5	3.64 ± 0.21	2.94 ± 0.21	p < 0.002, NS, NS*
TSH (μIU/ml)	0.03 ± 0.01	1.3 ± 0.2	3.1 ± 0.5	2.9 ± 0.3	p < 0.001 p* < 0.01, NS**

GD- Graves' disease HT- Hashimoto's thyroiditis NTMG- non-toxic multinodular goiter
p, Statistical significance between group A and C; p*, statistical significance between group A' and C; p**, statistical significance between group B and C;
X, standard deviation; NS, no statistical significance.

ISSN: 1756-6614