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Table 1 Demographic data, biochemical and immunological findings and treatment of probands with thyroid autoimmunity and their first or second degree relatives

From: Eye findings and immunological markers in probands and their euthyroid relatives from a single family with multiple cases of thyroid autoimmunity

Subjects

Age (range yr)

Sex (F/M)

Mean serum TSH 1(mIU/L)

Positive TPO 2antibodies

TSH-R Ab 3

Treatment 4

TBII

TSI

L-T 4

RAI ATD

 

Probands

GD5 with ophthalmopathy (n = 3)

52-75

2/1

1.84

2

2

0

3

3

1

Other thyroid disorders (n = 1)

77

1/0

6.52

1

0

0

1

0

0

Relatives

No documented thyroid disorders (n = 11)

13-54

7/5

1.26

2

0

1

0

0

0

  1. 1 TSH = thyroid stimulating hormone (normal range 0.3-4.0 mIU/L).
  2. 2 TPO = thyroid peroxidase (cut-off titre 100).
  3. 3 A positive test for thyroid stimulating antibodies (TSI) was taken as a % B/BO >19%, a positive test for TSH-R binding inhibitory immunoglobulin (TBII) was taken as >1.5 IU/Litre.
  4. 4 Number of patients treated with thyroxine (L-T4), 131I or antithyroid drugs (ATD).
  5. 5 GD = Graves’ disease.
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Thyroid Research

ISSN: 1756-6614