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Thyroid Research

Open Access

Metabolomics provides new information on the changes occurring in thyroid tumours

  • Waldemar Balcerzak1,
  • S Deja2,
  • P Młynarz3,
  • A Ząbek3,
  • M Orczyk-Pawiłowicz4,
  • M Głód1,
  • T Dawiskiba5 and
  • D Pawełka1
Thyroid Research20136(Suppl 2):A3

Published: 5 April 2013


AdenomaGoiterMalignant LesionHealthy TissueThyroid Tissue

Metabolomics is a part of systems biology dealing with the determination of qualitative and quantitative profile of low molecular weight compounds (metabolites) present in body fluids and tissues of living organisms. Metabolic composition is strongly dependent on the state of homeostasis and any deregulation should affect it. For this reason, there is now increased interest in metabolomics as a potential tool to support cancer research. At the same time the analysis of metabolic pathways involved in the process of carcinogenesis provides the possibility of a more complete understanding of the mechanisms that are critical for tumour biology.

In this study, 1H NMR measurements were performed for thyroid tumour tissue and healthy tissue homogenates and analyzed by chemometric manner. Multivariate analysis of the data using the PCA, PLS-DA and OPLS-DA methods allowed a precise separation from normal thyroid tissue of all tumours originating in both benign and malignant lesions. In addition, classification of nodular goiter, follicular adenoma and malignant tumours was possible with comparable efficacy.

Authors’ Affiliations

First Department and Clinic of General, Gastroenterological and Endocrinological Surgery, Wrocław, Poland
Faculty of Chemistry, Opole University, Opole, Poland
Department of Bioorganic Chemistry, Wrocław University of Technology, Wrocław, Poland
Department of Chemistry and Immunochemistry, Wrocław, Poland
Department and Clinic of Vascular, General and Transplantation Surgery, Wrocław, Poland


© Balcerzak et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.