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Table 1 Types of thyroid hormones transporters and their iodothyronine derivates [16]

From: Hypothyroidism and brain developmental players

Transporter a

Iodothyronine derivates

Specificity b

MCT8

T3, T4, rT3, T2

+++

MCT10

T3, T4

++

OATP1A1

T3, T4, rT3, T2, T4S, T3S, rT3S, T2S

+

OATP1A2

T4, T3, rT3

OATP1A3

T4, T3

OATP1A4

OATP1A5

OATP1B1

T4, T3, T3S, T4S, rT3S

OATP1B2

T3, T4

OATP1B3

rT3, T4S, T3S, rT3S

OATP1C1

T4, rT3, T3, T4S

++

OATP2B1

T4

+

OATP3A1 (V1/V2)

++

OATP4A1

T3, T4, rT3

+

OATP4C1

T3, T4

OATP6B1

OATP6C1

LAT1

T3, T4, rT3, T2

LAT2

NTCP

T4, T3, T4S, T3S

++

  1. aThe human protein symbol is presented, if TH transport has been demonstrated in different species including humans. bIf a transporter only transports iodothyronine derivatives, specificity is high (+++). If fewer than five other ligands are known, specificity is moderate (++). If more than five ligands are known, the transporter is denoted as multispecific (+).