Table 1 Univariate tests for factors between patient with non-elated and elated TSH
From: The impact of Lithium on thyroid function in Chinese psychiatric population
Factors | Non-elated TSH (N = 169) | Elated TSH (N = 93) | p |
|---|---|---|---|
Male | 81 (47.9 %) | 28 (30.1 %) | 0.005*a |
Female | 88 (52.1 %) | 65 (69.9 %) | |
Primary Psychiatric Diagnosis | 0.573b | ||
Schizophrenia/Schizoaffective | 51 (30.1 %) | 33 (35.5 %) | |
Disorder/Psychosis | |||
Bipolar Affective Disorder/Mania | 86 (50.9 %) | 46 (49.5 %) | |
Depression/Anxiety | 26 (15.4 %) | 11 (11.8 %) | |
Mental Retardation | 3 (1.8 %) | 3 (3.2 %) | |
Others | 3 (1.8 %) | 0 (0.0 %) | |
Secondary Psychiatric Diagnosis | 0.309b | ||
Personality Disorder | 1 (0.6 %) | 1 (1.1 %) | |
Mental Retardation | 6 (3.5 %) | 1 (1.1 %) | |
Substance Abuse | 5 (3.0 %) | 1 (1.1 %) | |
Autistic Spectrum Disorder | 2 (1.2 %) | 1 (1.1 %) | |
Others | 0 (0.0 %) | 2 (2.1 %) | |
Nil | 155 (91.7 %) | 87 (93.5 %) | |
Physical Comorbidities | |||
Hypertension | 0.505a | ||
Yes | 25 (14.8 %) | 11 (11.8 %) | |
No | 144 (85.2 %) | 82 (88.2 %) | |
Diabetes | 0.911a | ||
Yes | 21 (12.4 %) | 12 (13 %) | |
No | 148 (87.6 %) | 81 (87 %) | |
Hyperlipidaemia | 0.410a | ||
Yes | 18 (10.7 %) | 7 (7.5 %) | |
No | 151 (89.3 %) | 86 (92.5 %) | |
Cardiovascular disorders | 0.617b | ||
Yes | 2 (1.2 %) | 2 (2.2 %) | |
No | 167 (98.8 %) | 91 (97.8 %) | |
Types of Lithium taking | 0.073**a | ||
Lithium CR | 141 (83.4 %) | 69 (74.2 %) | |
Lithium IR | 28 (16.6 %) | 24 (25.8 %) | |
Frequency of Lithium per day | 0.311b | ||
Once | 147 (87.0 %) | 75 (80.6 %) | |
Twice | 20 (11.8 %) | 17 (18.3 %) | |
Three times | 2 (1.2 %) | 1 (1.1 %) | |
Use of depot injection | 0.008*b | ||
Yes | 22 (13.0 %) | 3 (3.2 %) | |
No | 147 (87.0 %) | 90 (96.8 %) | |
Use of oral antipsychotics | 0.421a | ||
Yes | 129 (76.3 %) | 75 (80.6 %) | |
No | 40 (23.7 %) | 18 (19.4 %) | |
Use of antidepressant | 0.746a | ||
Yes | 62 (36.7 %) | 36 (38.7 %) | |
No | 107 (63.3 %) | 57 (61.3 %) | |
Use of Benzodiazepine | 0.742a | ||
Yes | 80 (47.3 %) | 46 (49.5 %) | |
No | 89 (52.7 %) | 47 (50.5 %) | |
Use of Carbamazepine | 0.669b | ||
Yes | 3 (1.8 %) | 3 (3.2 %) | |
No | 166 (98.2 %) | 90 (96.8 %) | |
Use of Valproate Sodium | < 0.001*a | ||
Yes | 18 (10.7 %) | 31 (33.3 %) | |
No | 151 (89.3 %) | 62 (66.7 %) | |
Use of other mood stabilizers | 1.000a | ||
Yes | 5 (3.0 %) | 2 (2.2 %) | |
No | 164 (97.0 %) | 91 (97.8 %) | |
Use of non-psychiatric medications | 0.786a | ||
Yes | 77 (45.6 %) | 44 (47.3 %) | |
No | 92 (54.4 %) | 49 (52.7 %) | |
Age, mean (SD) | 48.47 (12.188) | 48.76 (12.473) | 0.852c |
Serum Lithium Level (μmol /L), mean (SD) | 541.30 (217.701) | 639.14 (212.984) | 0.001*c |
Dosage of Lithium (mg), median (IQR) | 800 (675–1000) | 800 (600–800) | 0.364d |