Fig. 1

Main results from the observational studies [13,14,15,16] that detected an association between the use of antihyroid drugs in early pregnancy and birth defects. The figure illustrates the prevalence of birth defects in non-exposed children and in children exposed to maternal treatment with Propylthiouracil (PTU) or Methimazole (MMI) in early pregnancy. *indicates statistical significant difference for comparison to the non-exposed group