Table 1 Observational studies on the association between the dose of Methimazole used in early pregnancy and outcome of birth defects
Author | Year | Country | Data source | Exposed (n)a | Dose definition | Associationb |
|---|---|---|---|---|---|---|
Momotani et al. [10] | 1984 | Japan | Medical records | 243 | Cumulative dose (range: 10–1680 mg) Daily dose (categories: 5, 10, 15, 20, and ≥ 30 mg) | No |
Yoshihara et al. [13] | 2012 | Japan | Medical records | 1231 | Daily dose (mean: 5 mg/day, standard deviation: 8.1 mg) | No |
Seo et al. [14] | 2018 | Korea | Nationwide registers | 1120 | Cumulative dose (categories: 1–126, 127–260, 261–495, and > 495 mg) | Yes |