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Table 1 Clinicopathological characteristics in hereditary MTC patients and in sporadic MTC patients

From: Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate

Variable Total Sporadic MTC Hereditary MTC p-value
No. of patients 46 28 18  
Age at surgery, yrs. a 53 (9–80) 59 (25–80) 28 (9–59) < 0.001
Sex, no. (%)
 Male 19 14 5 0.220
 Female 27 14 13  
Max. tumor size at surgery, mma 20 (5–75) 20 (9–63) 21 (5–75) 0.991
Extrathyroid extension:b
 Yes 2 1 1 0.999
 No 46 27 17  
Ki67 labeling index:
  < 5% 39 25 14 0.163
 5–10% 2 0 2  
  > 10% 4 3 1  
 Unknown 1 0 1  
pN (8th UICC/AJCC staging system):
 pN0 3 1 2 0.594
 pN1a 3 2 1  
 pN1b 40 25 15  
Stage (8th UICC/AJCC staging system):
 I 3 1 2 0.594
 III 3 2 1  
 IVA 40 25 15  
Ct-DR, per year:a 0.17 (−1.25–5.70) 0.17 (−0.42–5.70) 0.21 (−1.25–1.90) 0.753
hTV-DR, per yr a 0.60 (0.26–3.65) 0.50 (0.26–1.10) 1.21 (0.50–3.65) < 0.001
Observation period, yrs 4.6 (1.0–4.6) 4.6 (1.0–4.6) 4.6 (1.0–4.6) 0.079
No. of Ct measurements 9 (4–10) 7 (5–10) 9 (4–9) 0.018
  1. Ct-DR calcitonin doubling rate, hTV-DR hypothetical tumor-volume doubling rate, MTC medullary thyroid carcinoma
  2. aMedians are in parentheses. bSignificant extension based on intraoperative findings