Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate

Table 1 Clinicopathological characteristics in hereditary MTC patients and in sporadic MTC patients

Variable	Total	Sporadic MTC	Hereditary MTC	p-value
No. of patients	46	28	18
Age at surgery, yrs. ^a	53 (9–80)	59 (25–80)	28 (9–59)	< 0.001
Sex, no. (%)
Male	19	14	5	0.220
Female	27	14	13
Max. tumor size at surgery, mm^a	20 (5–75)	20 (9–63)	21 (5–75)	0.991
Extrathyroid extension:^b
Yes	2	1	1	0.999
No	46	27	17
Ki67 labeling index:
< 5%	39	25	14	0.163
5–10%	2	0	2
> 10%	4	3	1
Unknown	1	0	1
pN (8th UICC/AJCC staging system):
pN0	3	1	2	0.594
pN1a	3	2	1
pN1b	40	25	15
Stage (8th UICC/AJCC staging system):
I	3	1	2	0.594
III	3	2	1
IVA	40	25	15
Ct-DR, per year:^a	0.17 (−1.25–5.70)	0.17 (−0.42–5.70)	0.21 (−1.25–1.90)	0.753
hTV-DR, per yr ^a	0.60 (0.26–3.65)	0.50 (0.26–1.10)	1.21 (0.50–3.65)	< 0.001
Observation period, yrs	4.6 (1.0–4.6)	4.6 (1.0–4.6)	4.6 (1.0–4.6)	0.079
No. of Ct measurements	9 (4–10)	7 (5–10)	9 (4–9)	0.018

Ct-DR calcitonin doubling rate, hTV-DR hypothetical tumor-volume doubling rate, MTC medullary thyroid carcinoma
^aMedians are in parentheses. ^bSignificant extension based on intraoperative findings

ISSN: 1756-6614