Table 2 The relationship between permanent congenital hypothyroidism (CH) and potential risk factors
| Variables |
Control N = 340 |
Permanent CH N = 136 | OR (95% CI) | P value* |
|---|---|---|---|---|
| Parental consanguineous marriage | ||||
| No | 296 (87.1) | 106 (77.9) | 1 | 1 |
| Yes | 44 (12.9) | 30 (22.1) | 2.31 (1.6–3.3) | 0.001 |
| Betadine usage | ||||
| No | 336 (98.8) | 130 (95.5) | 1 | 1 |
| Yes | 4 (1.2) | 6 (4.4) | 3.8 (1.07–13.8) | 0.039 |
| Sex | ||||
| Boy | 181 (53.2) | 74 (54.4) | 1 | 1 |
| Girl | 159 (46.8) | 62 (56.6) | 0.95 (0.64–1.42) | 0.81 |
| History of CH in the first degree family | ||||
| No | 335 (98.5) | 121 (89) | 1 | 1 |
| Yes | 5 (1.5) | 15 (11) | 8.25 (2.93–23.2) | 0.001 |
| Neonatal jaundice | ||||
| No | 299 (87.9) | 84 (61.8) | 1 | 1 |
| Yes | 41 (12.1) | 52 (38.2) | 4.5 (2.8–7.26) | 0.001 |
| Birth weight (gr) | ||||
| < 2500 | 19 (5.6) | 21 (15.4) | 1 | 1 |
| 4000–2500 | 308 (90.6) | 110 (80.9) | 0.29 (0.14–0.56) | 0.01 |
| > 2500 | 13 (93.8) | 5 (3.7) | 0.31 (0.09–1.04) | 0.059 |
| Mother’s age (year) | ||||
| < 20 | 43 (12.6) | 24 (17.6) | 1 | 1 |
| 20–30 | 97 (28.5) | 48 (35.3) | 1.6 (0.89–3.5) | 0.1 |
| 30–40 | 127 (37.4) | 41 (30.1) | 1 (0.89–2.94) | 0.11 |
| > 40 | 73 (21.5) | 23 (16.9) | 0.31 (0.57–1.8) | 0.93 |