Table 2 Longitudinal studies of thyroid function in adults and elderly
Author and year | Cohort and country | Number | Mean age, years | Follow up years | Assay Used | Key findings |
|---|---|---|---|---|---|---|
Bremner, 2012 [97] | Busselton health survey, Australia | 908 | 46 | 13 | Immulite 2000 chemiluminescent analyzer (Siemens) | Mean TSH increased from 1.49 to 1.81 mIU/L; No change in FT4 |
Waring, 2012 [98] | Cardiovascular Health Study All-Stars Study, USA | 843 | 85 | 13 | Elecsys 2010 analyzer (Roche) | Mean TSH increased from 2.60 to 2.94 mIU/L; FT4 increased from 1.20 to 1.22 pmol/l; Total T3 decreased from 116.9 to 102.0 pmol/l |
Chaker, 2016 [99] | The Rotterdam study, Netherlands | 1225 | 67 | 6·5 | electrochemiluminescence immunoassay, “ECLIA” (Roche) | No change in TSH; FT4 increased by a mean of 4.5 pmol/L |
Mammen, 2017 [100] | Baltimore Longitudinal Study of Aging, USA | 640 | 66 | 7 | immunoassay Vista Chemiluminescence,(Siemens) | No change in means of TSH, FT4, and FT3. Changes in TSH more common in older participants |
Roberts, 2018 [101] | Birmingham Elderly Thyroid Study, UK | 2936 | 77 | 5 | electrochemiluminescence immunoassay, “ECLIA” (Roche) | No change in TSH or FT4. |